The involvement of TREM2 in innate immune memory

Innate immune memory is a biological phenomenon in which immune cells begin to reshape when the innate immune system responds to immune stimuli. After the initial immune response to an environmental stimulus, cells undergo epigenetic reprogramming to alter the subsequent immune response, either enhancing or suppressing the subsequent inflammatory response. Triggering receptor expressed on myeloid cells 2 (TREM2), a member of the TREM immunoglobulin superfamily, regulates the physiological function of microglia and plays an important role in neuroinflammation. However, the role of TREM2 in innate immune memory is still unclear.