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The Mitochondrial Regulatory Network: Subcellular localization of Non-Coding RNA in the Heart

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https://www.ncbi.nlm.nih.gov/sra/SRP213856
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Non-coding RNAs (ncRNAs) mediate processes such as transcription, translation, and other diverse biological functions within the cell. A particular class of ncRNA, long ncRNA (lncRNA), can act as competitive endogenous RNAs, sequestering mRNAs and microRNAs; but, sequestration requires appropriate stoichiometric ratios to be efficient. The purpose of the current study is to characterize the subcellular localization of ncRNA within the mitochondrion, and to understand how import/export mechanisms may dictate changes in RNA diversity during disease progression.
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2020-12-24
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