Cdkn2a

Enables DNA-binding transcription factor binding activity; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Nov 2024]

此数据集包含能够激活DNA结合转录因子结合活性、MDM2/MDM4家族蛋白结合活性和酶抑制剂活性的数据。涉及多种生物过程，包括淋巴细胞增殖的负向调控、凋亡过程的正向调控以及DNA模板转录的调控。在包括角质细胞增殖、乳腺上皮细胞增殖的负向调控和蛋白质代谢过程的负向调控等过程中发挥上游作用或位于其中。位于细胞质和颗粒成分中，构成包含蛋白质的复合体的一部分。在包括中枢神经系统、眼睛、泌尿生殖系统、免疫系统以及脐动脉在内的多个结构中表达。用于研究高级别胶质瘤、恶性周围神经鞘瘤、多发性黑色素瘤和多发性胰腺癌。与该基因相关的人类同源基因涉及多种疾病，包括多发性乳腺癌、多发性癌、多发性血液学癌症、多发性高级别胶质瘤和多发性黑色素瘤。与人类CDKN2A（周期依赖性激酶抑制因子2A）同源。[由基因组资源联盟提供，2024年11月]