Neocryptolepine Derivatives Anti-tumor Database System (NDADS)

Neocryptolepine is a natural alkaloid isolated from the African climbing plant Paeonia lactiflora, belonging to the indole quinoline alkaloid class. This compound has become a natural precursor widely studied by medicinal chemists due to its diverse biological activities, especially its potential applications in anti-tumor, anti-inflammatory, anti malaria and other fields. As a natural product with multiple biological activities,Neocryptolepine has great potential in cancer treatment research. Through in-depth research and development of the Neocryptolepine, it may provide new treatment options for cancer patients in the future.Cancer, as a global health challenge, has long plagued the medical community and patients. It is a disease caused by the unlimited proliferation, invasion, and metastasis of abnormal cells, which can affect any part of the human body. With the change of lifestyle, the aggravation of environmental pollution and the trend of aging population, the incidence rate of cancer has increased year by year and has become the second leading cause of death in the world. Despite its enormous potential in cancer treatment, the diversity, mechanisms, and unknown targets of action make it extremely challenging to obtain Neocryptolepine  anti-cancer pathways from it. In addition, it is difficult to search for systematic information on anti-cancer Neocryptolepine from a large amount of information such as the internet. Neocryptolepine derivatives, as a natural compound, have shown great potential and diversity in cancer treatment. Despite facing challenges in screening and utilization, they remain important resources for drug development.In order to construct the NDADS database, authoritative literature search websites such as Pubmed and Google Scholar were used to systematically collect key information on the generic name, anti-tumor activity, cancer type, mechanism of action, and targets of Neocryptolepine and its derivatives using keywords such as Neocryptolepine, Cancer, and Target. On this basis, all data were integrated and included in the data of 85 Neocryptolepine derivatives in the laboratory, ultimately forming a database containing information on 203 anti-tumor compounds derived from Neocryptolepine derivatives. In order to integrate and evaluate numerous research resources and results, the Neocryptolepine derivatives anti-tumor database can provide rich retrieval and analysis tools, such as cross database retrieval, citation retrieval, journal retrieval, etc., enabling users to easily search for anti-tumor related information of Neocryptolepine derivatives. Supplement the current inclusion status, covering the names, structures, molecular weights, activities, functions, cancer types, cancer cells, targets/signaling pathways, references, and corresponding website sources of various compounds. This interface supports the query function for the content of the Neocryptolepine derivatives mentioned above. Therefore, the anti-tumor database of the Neocryptolepine derivatives will help to study the potential of Neocryptolepine derivatives in the treatment of cancer from multiple aspects such as activity, structure, method of action, and target, assisting in cancer treatment and improving cancer survival rate.