Tumor biology is determined not only by immortal cancer cells but also its tumor microenvironment consisted of non-cancerous cells and extracellular matrix, together they dictate pathogenesis and resp
Immunotherapies such as immune checkpoint blockade (ICB) have revolutionized cancer treatment, yet quality of life and continuation of therapy can be constrained by development of off-target tissue to
Tumor progression largely depends on the presence of alternatively polarized (M2) tumor-associated macrophages (TAMs), whereas the classical M1-polarized macrophages can promote anti-tumorigenic immun
The lack of predictive preclinical models is a fundamental barrier to translating knowledge about the molecular pathogenesis of cancer into improved therapies. Insertional mutagenesis (IM) in mice is
