Performance of our predictive models when trained on the Sequenced Treatment Alternative to Relieve Depression (STAR*D) dataset, and externally evaluated on the Canadian Biomarker Integration Network in Depression (CAN-BIND-1) trial, predicting both response and remission according to the Quick Inventory of Depressive Symptomatology, Self Report Version (QIDS-SR) scale.

See Methods for our definition of these outcomes. No feature selection was used before running the models. Additional performance metrics and statistics are documented in S7 and S8 Tables.