Supplemental material, sj-sas-7-smm-10.1177_09622802211051089 for Allowing for stratification in sample size planning of two-arm trials with continuous or binary outcome: Overview and tutorial by Stef
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These
Interventions: TS-1+ Oxaliplatin+ Bevacizumab/TS-1+ Bevacizumab Primary outcome(s): DDC ; Duration of disease control Study Design: Single arm Non-randomized
In this article, we consider randomized trial design to evaluate interventions with spatially or spatio-temporally heterogeneous effects. A common approach in this setting is the cluster randomized tr