Methylation Mediated Silencing of Protein Kinase C Zeta Induces Apoptosis Avoidance through ATM/Chk-2 Inactivation in Dedifferentiated Chondrosarcoma

To examine methylation levels of genes, we performed whole-genome bisulfite sequence for 2 cell lines: NDCS-1, which was established from dedifferentiated chondrosarcoma and had a fast-growing phenotype, and OUMS-27, which was established from conventional chondrosarcoma and had a slow-growing phenotype. WGBS in 2 chondrosarcoma cell lines: OUMS-27 and NDCS-1.