The CXCL12–CXCR4 axis plays a key role in the retention of stem cells and progenitors in dedicated bone marrow niches. It is well-known that CXCR4 responsiveness in B lymphocytes decreases dramaticall
Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map) Descriptor: Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ..
The CC-chemokines RANTES, macrophage inflammatory protein 1α (MIP-1α), and MIP-1β are natural ligands for the CC-chemokine receptor CCR5. MIP-1α, also known as LD78α, has an isoform, LD78β, which was
The interactions between chemokines and their receptors, particularly in the context of inflammation, are complex with individual receptors binding multiple ligands and individual ligands interacting
CCR1+ and CCR5+ refer to Ba/F3 cells that have been transfected with these receptors.–Indicates value was not measured.*Denotes CCL4 was included when assaying CCR5 expressing cells.#CM denotes condit
