Muscle Inflammation is Regulated by NF-kB From Multiple Cells to Control Distinct States of Wasting in Cancer Cachexia

Mononuclear cells from skeletal muscle isolated from LLC tumor bearing IKK-bflox or Pax7 Cre-ErT x IKKb-flox mice were isolated at humane endpoint. RNA was isolated and RNA seq run to determine if muscle progenitor cell specific NF-kB activity regulates the expression of inflammatory genes in the muscle microenvironment of cancer cachexia.