APE1 N174A Substrate Complex with Abasic DNA

APE1 N174A Substrate Complex with Abasic DNA Descriptor: DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA repair nuclease/redox regulator APEX1, ... Authors: DeHart, K.M, Freudenthal, B.D. Deposit date: 2024-09-20 Release date: 2024-10-09 Last modified: 2025-10-29 Method: X-RAY DIFFRACTION (2.29 Å) Cite: APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis. J.Biol.Chem., 301, 2025