Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses. Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses

To explore the impact of nasal commensal viruses on the onset and progression of allergic rhinitis, We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of CD45+ cells in the nasal mucosa of mice treated with Vehicle, Ribavirin, Vehicle-OVA, or Ribavirin-OVA. Overall design: CD45+ cells in the nasal mucosa of mice were isolated by Fluorescence-activated cell sorting (FACS) and analyzed using scRNAseq.