Inferring dynamic regulatory programs in non-stationary expression time courses with applications to early human neural development
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We generated RNA-seq data to measure transcriptional profiles of twenty hPSC-derived NSC populations, representing distinct regions of the developing human hindbrain and rostral cervical spinal cord. These cells are differentiated using a protocol that induces collinear activation of region-specific HOX genes during exposure to FGF8 and Wnt signaling (Lippmann et al, 2015 PMID:25843047). By transitioning to media containing retinoic acid after varying durations of Wnt signaling, NSCs are generated with unique rostrocaudal identities that uniformly express the neuroectodermal marker Pax6 and form N-cadherin+ rosette structures in vitro.
提供机构：
University of Wisconsin Madison
创建时间：
2022-02-20
