Dataset for: iTRAQ-based proteomic and bioinformatic characterization of human mast cell upon different IAV (H1N1 and H5N1) infection

In our previous study, it was demonstrated that mast cell can support replication of Influenza A virus (IAV) and how this occurs is poorly understood. At present, using quantitative mass spectrometry, we analyzed proteome of human mast cells (HMCs) infected with different IAV strains at 12h post-infection (12 hpi). More 41 differentially expressed proteins (DEPs) of global HMCs caused by H5N1 (A/Chicken/Henan/1/04) virus than H1N1 (A/WSN/33) virus. Bioinformatic analyses confirmed that H1N1 significantly regulated the RNA degradation pathway via CNOT4 expressing highly while apoptosis could be suppressed by H5N1 virus down regulated by p53 signaling pathway with P≤0.05 at 12 hpi. HIF-1 signal pathway of HMCs was more susceptible to the infection of H5N1 than H1N1 virus.