Additional file 4 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Microglia, the resident immune cells of the central nervous system (CNS), are responsible for maintaining homeostasis in the brain by clearing debris and are suggested to be inefficient in Alzheimer’s
Alzheimer's disease (AD) is closely linked to the accumulation of neurotoxins derived from Aβ and tau, as well as cognitive impairment. The premise of this project is that the imbalance in the endocan
This study developed triptolide-loaded liposomes (TPL) for intranasal delivery to mitigate systemic toxicity of free triptolide (TP) while enhancing therapeutic efficacy in neuroinflammatory and Alzhe
BackgroundThe objective of this study was to determine whether treatment with the nonselective nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows cognitive decline in patients with Alzheim
To profile gene expression differences in astrocytes after chemogenetic neuronal activation in different mouse brain regions. Furthermore, we also sought to profile gene expression differences between