The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET

To investigate the function of PLK1 in the regulation of lung cancer development in mice, we performed genetic crosses to incorporate a Plk1 transgene into the KP mouse model (herein KPP) . We then performed gene expression profiling analysis using data from RNA-seq of tumors from either cohort respectively. Overall design: Comparative gene expression profiling analysis of RNA-seq data for KP and KPP tumors.