Viral load-independent disease-influencing effects of HLA-B*57-containing genotypes.

Results are from nested multivariate Cox proportional hazards models for the outcome of time to AIDS (1987 criteria) for subjects assigned to B*57-PD and B*57-NPD before (none, model 1) and after adjustment for covariates individually (models 2 to 6) or in unison (models 7 to 10). Data is presented as relative hazard (RH) with 95% CI and P values. The reference group for all the comparisons is those who lack a B*57 allele (relative hazard = 1). N, number of subjects. B*57-PD represents subjects who possess B*57-containing genotypes that associate with progressive disease whereas B*57-NPD represents subjects who possess B*57-containing genotypes that associate with non-progressive disease (as shown in Figure 4D).