Antimicrobial resistance rates of <i>S. pneumonia.</i>

Notes: aNumber of resistant strains/total number of strains in each study, expressed as %. Methods and breakpoints applied: [41] Methods and breakpoints: not defined. [50] Methods: disk diffusion and Etest (penicillin): breakpoint penicillin intermediate resistance MIC 0.12-1 µg/ml; resistance ≥2.0 µg/ml (NCCLS/CLSI 2002 M100 S12). [46] Methods: agar dilution; breakpoint penicillin intermediate resistance MIC 0.12-1 µg/ml, resistance ≥2.0 µg/ml (NCCLS/CLSI 2001M7-A4). [48] Methods: disk diffusion and Etest; breakpoints penicillin intermediate resistance: MIC 0.12-1 µg/ml, resistance ≥2 µg/ml (CLSI 2006 M100-S16). [43] Methods: broth microdilution; breakpoints penicillin intermediate resistance: 0.12-1 µg/ml; resistance: MIC ≥2 µg/ml (CLSI). [39] Method: disk diffusion; breakpoints according to NCCLS/CLSI (details not given). NAMRU: Methods: disk diffusion and Etest; breakpoints (CLSI 2007). IPC: Methods: disk diffusion and Etest; breakpoint penicillin intermediate resistance: MIC >0.06 mg/l, resistance >2 mg/l (Recommendations Société Française de Microbiologie (RSFM) 2007). SH AHC: Methods: disk diffusion and Etests; breakpoints (CLSI 2011). ACH: Methods: disk diffusion and Etest; breakpoints (CLSI 2012). bSum of all resistant organisms/sum of all organisms tested.