Gene expression profiling reveal different molecular pattern in G-protein coupled receptor protein signaling pathway between early- and late-onset preeclampsia. Homo sapiens

Background: Early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) has been regarded as two different phenotypes with heterogeneous manifestation. The underlying mechanisms remain elusive. Aim to gain insight into the pathogenesis of the two traits, we analyzed the placental gene expression profiles in preeclampsia placentas. Methods: Whole genome-wide microarray was used to describe the gene expression profiles in the placenta tissues from patients with early-(n=7; 36 weeks) PE and their controls who delivered preterm (n=5;36 weeks) Genes were selected as differentially expressed upon a fold-change≥2 and q-value36 weeks) PE and their controls who delivered preterm(n=5;36 weeks). Pooled controls who delivered at term were labled with cy5.