Association between hypomagnesemia, estimated glomerular filtration rate, fasting glucose, and bone mineral density with the lead replicated SNPs showing genome-wide significant associations with serum magnesium concentrations.

CHR, chromosome; CI, confidence interval; OR, odds ratio; SE, standard error; SNP, single nucleotide polymorphism.
*Adjusted for age, sex, and study center (if applicable); the association reported is for the magnesium-lowering allele.
†Includes the following CHARGE cohorts: ARIC (N = 8,122), RS (N = 4,378); OR is from logistic regression of hypomagnesemia (<0.7 mmol/L).
‡Includes the following CHARGE cohorts: AGES (N = 3,219), ARIC (N = 8,069), CHS (N = 3,282), FHS (N = 2,861), RS (N = 4,374); beta is for natural log transformed eGFR (ml/min/1.73 m2).
§Results are from meta-analyses of up to 46,180 individuals from 21 MAGIC cohorts in non-diabetics of European ancestry; beta is for each unit increase in fasting glucose (mmol/L) and is additionally adjusted for geographic covariates (where applicable) and age squared (FHS only).
∥Results are from meta-analyses of 19,195 individuals from five cohorts in the GEFOS consortium; beta is for per allele-copy change of BMD as measured in standard deviations from the population mean and is adjusted for age, weight, sex, and study. Associations with lumbar spine BMD were similar to femoral neck BMD.