1‑Hydroxybenzotriazole-Assisted, N‑Heterocyclic Carbene Catalyzed β‑Functionalization of Saturated Carboxylic Esters: Access to Spirooxindole Lactones
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A 1-hydroxybenzotriazole-assisted, N-heterocyclic carbene catalyzed direct β-functionalization of saturated carboxylic esters is disclosed. This formal [3 + 2] annulation reaction of carboxylic esters with isatins affords optically pure spirooxindole lactones (on gram scale) bearing two vicinal stereogenic centers. A dual role of HOBt is proposed based on controlled experiments to rationalize the enhancement of diastereoselectivity and enantioselectivity.
创建时间：
2016-11-14
