Study of dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest. Study of dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest

For studing dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest, samples were treated with the DNA-damaging agent bleomycin at 0 ug/ml, 2 ug/ml and 40 ug/ml for 2 h. High-resolution time course analysis of gene expression in DNA damage-induced cellular senescence and transient cell-cycle arrest was used to explore the transcriptomic differences between different cell fates after DNA damage response. Overall design: Examination of IMR90 cells with different levels of DNA damage.