Source of diagnosis and temporal relationship between the first positive galactomannan and diagnosis in 18 patients with invasive fusariosis.

GMI = galactomannan antigen; NP = not performed; NA = not applicable; the signal (+) means that serum galactomannan antigen became positive after the diagnosis of invasive fusariosis, and the signal (−) means that serum galactomannan antigen became positive before the diagnosis of invasive fusariosis*This patient had 4 positive GMI tests before the first clinical manifestation of fusariosis and 7 positive tests before the diagnosis.**This patient had 2 positive GMI tests 25 days before the diagnosis of fusariosis, and another positive test on the day of a positive blood culture for Fusarium. During this 25-day period the patient received anidulafungin for the treatment of a candidemia, and had 5 negative GMI tests, with values >0.4.***This patient had 3 positive GMI tests while neutropenic, with focal ground-glass infiltrates in the left lung. Neutropenia resolved and the patient received posaconazole prophylaxis for the subsequent cycle of chemotherapy. Eleven days after the last positive GMI test he complained of pain and edema in the left knee. The edema increased when he became neutropenic, and a puncture was performed 25 days after the first symptom. During this period 5 GMI tests were negative.