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C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

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NIAID Data Ecosystem2026-03-11 收录
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Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation. However, the role of C3a-C3aR signaling in regulating lung metastasis of breast cancer remains unknown.We performed various ex-vivo and in-vivo assays. Genetic and pharmacological C3aR blockade models were applied to investigate the role of C3a-C3aR in metastasis of breast cancer.

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2020-01-11
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