Presence of host genetic risk factors identifies RVR negative patients that will fail to achieve SVR on completion of therapy.

Patients that failed to achieve RVR after 4 weeks of treatment were analysed. Four different host genetic genotypes were identified based on the presence of 2 risk factors (IL28B-T allele, and presence of the NK cell gene KIR2DS3). Patients were stratified according to whether they ultimately achieved SVR or not within each genotype group and the counts obtained are shown. Based on these data, a suggested treatment strategy is shown with respect to supporting patients through treatment or terminating treatment early.