XPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor

We aimed to investigate the role of XPO1 in this rare leukemia subtype. ChIP-sequencing was performed for XPO1 and NUP214 (as surrogate for DEK::NUP214 protein), and found co-occupancy of both proteins in putative DEK::NUP214 target genes. Chromatin immunoprecipitation in FKH-1 cells. 24h after treatment with DMSO or eltanexor 400 nM, using antibodies against XPO1 and NUP214