Table_1_An Update of Long-Noncoding RNAs in Acute Kidney Injury.DOCX

Acute kidney injury (AKI) is a global public health concern with high morbidity, mortality, and medical costs. Despite advances in medicine, effective therapeutic regimens for AKI remain limited. Long non-coding RNAs (lncRNAs) are a subtype of non-coding RNAs, which longer than 200 nucleotides and perform extremely diverse functions in biological processes. Recently, lncRNAs have emerged as promising biomarkers and key mediators to AKI. Meanwhile, existing research reveals that the aberrant expression of lncRNAs has been linked to major pathological processes in AKI, including the inflammatory response, cell proliferation, and apoptosis, via forming the lncRNA/microRNA/target gene regulatory axis. Following a comprehensive and systematic search of the available literature, 87 relevant papers spanning the years 2005 to 2021 were identified. This review aims to provide and update an overview of lncRNAs in AKI, and further shed light on their potential utility as AKI biomarkers and therapeutic targets.

急性肾损伤（AKI）是全球公共卫生领域的一大关注焦点，其具有较高的发病率、死亡率和医疗费用。尽管医学取得了长足进步，但针对AKI的有效治疗方案仍较为有限。长非编码RNA（lncRNA）是非编码RNA的一个亚型，其长度超过200个核苷酸，在生物过程中发挥着极其多样的功能。近年来，lncRNA作为具有潜力的生物标志物和AKI的关键介质而崭露头角。同时，现有研究表明，lncRNA的异常表达与AKI中的主要病理过程有关，包括炎症反应、细胞增殖和凋亡，通过构建lncRNA/微RNA/靶基因调控轴实现。经过对现有文献的全面而系统的检索，共发现2005年至2021年间87篇相关论文。本综述旨在提供并更新关于AKI中lncRNA的概述，并进一步揭示其作为AKI生物标志物和治疗靶点的潜在价值。