Schuermann_Figure_4

Schuermann_Figure_4 - contains files demonstrating that the consecutive N-terminal truncation of HhC85S reverses the dominant negative phenotype. Supplemental folders contain confirming data obtained from independent driver lines en(2)-Gal4 and Hh_Gal4. Unimpaired multimerization as a prerequisite for direct contact with, and dominant-negative suppression of Hh activity are shown as excel-files. HhC85SD86-100 denotes a non-palmitoylated Hh variant that lacks inhibitory N-terminal peptide amino acids 86-100.