Building Cell Structure. In Art of Science

Caption: Using a groundbreaking new technique we can now build a human cell like a “3D puzzle” from scratch Participant category: Faculty/Project Scientist Department: School of Medicine Cells are like 3D puzzles, we know how they should look globally and how two puzzle pieces (e.g. proteins) connect locally, but we lack information of the intricate internal structure. In “A multi-scale map of cell structure fusing protein images and interactions” (Yue Qin, et al. Nature 2021), scientists demonstrate a groundbreaking AI approach in silico that enables scientists to build this “3D puzzle” from scratch. This innovative new approach to mapping cell structure combines microscopy, biochemistry and artificial intelligence to reveal previously unknown cell components. Here we see MuSIC interpreted as a 3D puzzle being assembled by a cohort of scientists.