The Prins Reaction Using Ketones: Rationalization and Application toward the Synthesis of the Portentol Skeleton
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We report a TMSI-promoted Prins cyclization reaction with ketones as carbonyl partners to prepare polysubstituted chiral spirotetrahydropyrans. In the presence of racemic 2-methylcyclohexanone a dynamic kinetic resolution occurred affording one stereoisomer. The observed enantiospecificity has been rationalized by DFT calculation.
创建时间：
2016-02-22
