Table 6 in The grass root endophytic fungus Flavomyces fulophazii: An abundant source of tetramic acid and chlorinated azaphilone derivatives

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天然产物抗肿瘤活性

真菌代谢产物

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Table 6 Antiproliferative activity of vermelhotin, hydroxyvermelhotin and flavochlorine A isolated from Flavomyces fulophazii culture extracts. Cell lineAntiproliferative activity (IC50, μM)vermelhotinhydroxy-flavochlorinereference avermelhotinADauSalA205812.1> 10067.90.3 1HepG210.1> 100> 1001.2 25.8 3A43119.9> 100> 1000.7U8728.6> 100> 1000.4 20.8EBC-120.0> 100> 1001.2SH-SY5Y12.9> 100> 1000.7HT-2931.4> 100> 1000.2 4HL-609.4> 100> 1000.02 5MonoMac-17.1> 100> 1000.62.2 36LCLC-37.0> 100> 1008.6103HHEK-29321.6> 100> 100nodataH83822.1> 100> 10010.2VERO> 100> 100> 100nodata

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National Public Health Center, Albert Fl´ori´an út 2 - 6, Budapest, 1097, Hungary; Research Group of Peptide Chemistry, Eotos Lorand University, Eotvos Lorand Research Network, Pazmany Peter setany 1 / A, Budapest, 1117, Hungary e National Institute of Pharmacy and Nutrition, Zrínyi u. 3, Budapest, 1051, Hungary; National Institute of Pharmacy and Nutrition, Zrínyi u. 3, Budapest, 1051, Hungary; Department of Plant Anatomy, Institute of Biology, Eotvos Lorand´University, Pazmany Peter setany 1 / C, Budapest, 1117, Hungary; National Public Health Center, Albert Florian út 2 - 6, Budapest, 1097, Hungary; National Public Health Center, Albert Florian út 2 - 6, Budapest, 1097, Hungary; Research Group of Peptide Chemistry, Eotos Lorand University, Eotvos Lorand Research Network, Pazmany Peter setany 1 / A, Budapest, 1117, Hungary e National Institute of Pharmacy and Nutrition, Zrínyi u. 3, Budapest, 1051, Hungary; Department of Plant Anatomy, Institute of Biology, Eotvos Lorand´Un

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2021-10-31