RNA-seq of bone marrow samples from acute myeloid leukemia patients and healthy individuals

Acute myeloid leukemia (AML) is the most common type of acute leukemia in
adults, characterized by the malignant transformation and uncontrolled
proliferation of abnormal myeloid hematopoietic progenitor cells in the
bone marrow. This study aims to analyze the pathogenesis and prognosis of
AML by performing RNA-seq on bone marrow samples from both AML patients
and healthy individuals. We collected a total of 20 bone marrow samples,
consisting of 10 samples from AML patients and 10 from healthy controls,
all of which were stored in liquid nitrogen. The study received ethical
approval (Ethical Approval Number: KY2024070), and all participants signed
informed consent forms. This dataset includes the RNA-seq data
from these samples. By analyzing the gene expression characteristics of
myeloid progenitor cells, we attempt to construct a prognostic model to
guide clinical treatment. These data not only aid in further exploring the
molecular mechanisms of AML but also serve to identify new biomarkers and
develop prognostic models, which are valuable for understanding the gene
expression differences between AML and healthy bone marrow samples. The
sharing of data from this study strictly adheres to ethical guidelines,
with all sample collection and usage approved by the ethics committee and
consented to by the participants.