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RNA-seq of precision cut liver slice (PCLS) culture before slicing and up to nine days after slicing

ChEBI2019-05-08 更新2026-07-12 收录

肝脏离体模型转录组学

药物肝毒性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-7364 数据链接链接失效反馈

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资源简介：

RNA-seq of precision cut liver slice (PCLS) culture before slicing and up to nine days after slicing

应用场景：

创建时间：

2019-05-08

药物肝毒性

斑马鱼毒理模型

Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control. A total of 16 sequencing experiments were performed (control N=8 and treatm

NIAID Data Ecosystem60

3'mRNA sequencing of hepatic RNA (MACE) at the time points 24h/48h after acetaminophen (APAP) (300mg/kg) administration

药物肝毒性

RNA测序分析

Hepatic RNA specimens from mice (C57BL/6) of the 4 groups (vehicle-treated at 24h/48h, n=6; acetaminophen (APAP)-treated (300mg/kg) at 24h/48h, n=7) were pooled at equal shares. Thereafter, pooled RNA

NIAID Data Ecosystem40

Table_3_A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies.docx

药物肝毒性

体外肝模型

The poor predictability of human liver toxicity is still causing high attrition rates of drug candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing authorization

NIAID Data Ecosystem30

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

药物肝毒性

氧化应激标志物

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

NIAID Data Ecosystem60

Gene expression data from primary human hepatocytes treated with GGF2 for 6, 24, or 72 h or 24 h with a 48 h washout.

药物肝毒性

基因表达谱分析

GGF2 is a recombinant human neuregulin-1β in development for chronic heart failure. Phase 1 clinical trials of GGF2 were put on hold when transient elevations in serum aminotransferases and total bili

NIAID Data Ecosystem40

RNA-seq of precision cut liver slice (PCLS) culture before slicing and up to nine days after slicing

资源简介：

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