Genotyping of Leptospira interrogans in clinical samples by target capture sequencing. Genotyping of Leptospira interrogans in clinical samples by target capture sequencing

Our data demonstrate the suitability of target capture technology for purifying very low quantities of Leptospira DNA from biological samples where the human genome is in vast excess. This enables deep sequencing of partial Leptospira genomes directly from clinical samples using next generation technologies and genotyping.