c-KIT kinase domain in complex with avapritinib derivative 12
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c-KIT kinase domain in complex with avapritinib derivative 12 Descriptor: Mast/stem cell growth factor receptor Kit, methyl ~{N}-[(1~{S})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]carbamate Authors: Teuber, A, Mueller, M.P, Rauh, D. Deposit date: 2023-07-11 Release date: 2023-12-27 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15, 2024
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2023-07-11
