Reactivity of AcHERV-based nanovaccines against HPV16, 18, and 58.

aIgG, IgA, and neutralization titers are serum dilution titer against each HPV pseudovirus and calculated with based on monovalent homologous titer. The 100% values indicate the 100% same to the titer values obtained for monovalent AcHERV-HPL1s (AcHERV-HP16L1, AcHERV-HP18L1, and AcHERV-HP58L1).bIFN-γ and IL-4 are number of spots per 106 splenocytes stimulated each pseudovirus HPV16, 18, and 58 and calculated with based on monovalent homologous spots. The 100% values indicate the 100% same to the spot numbers obtained for monovalent AcHERV-HPL1s.