Gla

Enables alpha-galactosidase activity. Involved in negative regulation of nitric oxide biosynthetic process and negative regulation of nitric-oxide synthase activity. Acts upstream of or within aorta development and glycosylceramide catabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and liver and biliary system. Used to study Fabry disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha). [provided by Alliance of Genome Resources, Nov 2024]

该基因激活α-半乳糖苷酶活性。参与一氧化氮生物合成过程的负调控及一氧化氮合酶活性的负调控。在主动脉发育和糖基Ceramide分解途径中位于上游或内部。位于细胞外空间和溶酶体中。在肾上腺、消化系统、大脑、泌尿生殖系统和肝脏及胆道系统中表达。用于研究法布里病。与法布里病相关的该基因的人类同源基因。与人GLA（α-半乳糖苷酶）同源。[由基因组资源联盟提供，2024年11月]