Identified gene interactions.

Six pairs of SNPs that represented interacting loci. Chr: chromosome and cytoband information. Nearest Gene: When the nearest annotated gene was >500 kb away from the SNPs, it was not listed. The trend p-values were obtained with the shared controls. The validation of allelic effect for loci with original trend p-values>0.05 is not presented. Validation status: Unavailable, data unavailable for validation; PPR, p-value of the proxy replication; Meta-analysis, susceptibility locus found by meta-analysis studies after the WTCCC study; Not significant, validation was not significant (P>0.05); Known region, a susceptibility region that was known at the time of the WTCCC study; PLV, p-value of the local validation. The last five columns contain the interaction results. Pure interaction p-values were obtained with the shared controls. Two-locus p-value (expanded): two-locus LRT p-value according to the search situation, and the two-locus p-values and the corresponding corrected p-values for the final significance were obtained in the expanded control analysis.*Bonferroni corrected PP