Xiaoyao Pill alleviates ulcerative colitis by inhibiting ferroptosis of enterocytes via activating Nrf2/Gpx4 signaling pathway

The treatment of ulcerative colitis (UC) remains a huge challenge worldwide.Xiaoyao Pill (XYP) is a classic TCM formula, which possesses several benefits, including soothingthe liver and invigorating the spleen. However, its protective effect on UC and its underlyingmechanisms are unknown. Purpose: Here we explored the protective effect and underlyingmechanism of XYP against dextran sulfate sodium (DSS)-induced colitis in mice.