Histone H4 binds to TLR4/MD-2 on THP-1 cells.
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https://figshare.com/articles/dataset/_Histone_H4_binds_to_TLR4_MD_2_on_THP_1_cells_/1621687
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(A) Overlapping peptides from histone H4 (100 μM) were incubated with heparinized blood for 12h at 37°C and CXCL10 release was measured by ELISA. (B) IRR20 was immobilized on a CM5 sensorchip and serial dilutions (200 nM – 12.5 nM) of the TLR4/MD-2 complex were applied in a flow. Steady-state affinity analysis was used to calculate the KD value (BIAevaluation software, GE Healthcare, Uppsala, Sweden). (C) The predicted structure of histone H4 was modeled using the UCSF Chimera software (http://www.cgl.ucsf.edu/chimera) with a hairpin loop corresponding to the TLR4-binding 20-mer peptide IRR20 marked in red.
创建时间：
2016-02-23
