16S rRNA (V1-V3) sequencing of fecal microbiota from SPF ApcMin/+;Il10-/- mice.

Colorectal cancer is the third leading cause of cancer death in men and women in the United States. An average of about 6 people die every hour of colorectal cancer and approximately 150,000 new cases are diagnosed annually. Colitis-associated colorectal cancer (CAC) represents a major form of cancer and a serious medical complication for patients suffering from inflammatory bowel disease (IBD). This project investigates the role of bacteria on development of CAC through the use of metagenomic, gnotobiotic and microbial genetic approaches. Our project identified cluster of bacteria associated with the development of colitis and colorectal cancer in ApcMin/+;Il10-/- mice.