Cost Effectiveness Analyses.

*Adjusting for baseline measures, and pre-specified covariates for age (individual level), and (at the cluster level) deprivation (IMD), site, and practice size. **Dominance: lower expected costs, with greater expected QALY gain. ‡WTP = willingness to pay; based in the assessment of incremental net benefit statistic, and WTP thresholds commonly applied in the UK NHS (NICE, 2013).