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Data for experiment 1 for interaction of Cu(II) and GYY4137: Redox Cycling and Temporal Dynamics Data for experiment 2 for enhanced antimicrobial efficacy via sustained Cu(I) generation Data for experiment 3 for elevated intracellular reactive oxygen species (ROS) induced Data for experiment 4 for cytocompatibility and proliferative dynamics of Cu(I)-Enriched Systems Data for experiment 5 for macrophage-mediated amplification of bactericidal activity Data for experiment 6 for Cu(I)-Mediated Macrophage Polarization Data for experiment 7 for In vivo toxicity