Here, we seek to address if an asthmatic host environment is associated with an increased emergence of influenza virus variants.. A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

The cardinal features of asthma were induced using a previously established RAGE knockout mouse model. Asthmatic and non-asthmatic mice were infected with H1N1, 6 days post infection lungs were harvested and viral RNA was extracted for sequencing