Asymmetric Synthesis of the Fully Elaborated Pyrrolidinone Core of Oxazolomycin A
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https://figshare.com/articles/dataset/Asymmetric_Synthesis_of_the_Fully_Elaborated_Pyrrolidinone_Core_of_Oxazolomycin_A/2473252
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资源简介:
The asymmetric synthesis of the key pyrrolidinone core, including a highly elaborated exocyclic carbon chain, of the γ-lactam β-lactone antibiotic oxazolomycin A is described. Principal features include the Birch reduction of an aromatic pyrrole nucleus, a late stage RuO4 catalyzed pyrrolidine oxidation, and a highly diastereoselective organocerium addition to an aldehyde.
创建时间:
2016-02-20



