<p>Data on 14 immortalized cell lines with details on their histologic, NF1 variant, passage and staining properties. Final row includes data on a subcloned heterozygous line (icNF98.4c). * indicates cell lines that were included in genomic profiling experiments. Excluded cell lines were not genomically profiled for the following reasons: icNF97.5 – the patient doesn’t meet diagnostic criteria for NF1, and the only germline mutation we can find seemed to be a silent variant via direct sequencing; icNF18.1 and icNF09.5 (same patient) - icNF18.1 is mostly heterozygous and the somatic mutation is in low frequency, we were unable to observe a second NF1 hit on icNF09.5 via direct sequencing; icNF93.1a - heterozygous and unable to observe a second NF1 hit via direct sequencing. ** morphology defined per rubric from Ortonne et al., 2018 (Neurology 91 (Suppl 1):S5-S13).</p>

Data on 14 immortalized cell lines with details on their histologic, NF1 variant, passage and staining properties. Final row includes data on a subcloned heterozygous line (icNF98.4c). * indicates cell lines that were included in genomic profiling experiments. Excluded cell lines were not genomically profiled for the following reasons: icNF97.5 – the patient doesn’t meet diagnostic criteria for NF1, and the only germline mutation we can find seemed to be a silent variant via direct sequencing; icNF18.1 and icNF09.5 (same patient) - icNF18.1 is mostly heterozygous and the somatic mutation is in low frequency, we were unable to observe a second NF1 hit on icNF09.5 via direct sequencing; icNF93.1a - heterozygous and unable to observe a second NF1 hit via direct sequencing. ** morphology defined per rubric from Ortonne et al., 2018 (Neurology 91 (Suppl 1):S5-S13).