Baseline characteristics of study participants.

*Participants with fever were defined as those children whose last temperature before intervention was greater than or equal to 37.5°C.
a“Others” referred to those who could not been recorded “the source of case” clearly in CRF.
b“No.” referred to the number of patients with Enterovirus71 virus-positive, while “(total)” referred to the total number of patients who underwent the detection of Enterovirus71 virus. In the first column, for example, “27(114)” indicated that 114 patients in the Jinzhen group underwent the detection of Enterovirus71 virus and 27 of them were identified as Enterovirus71 virus-positive.
c“No.” referred to the number of patients with Coxsackievirus A16 virus-positive, while “(total)” referred to the total number of patients who underwent the detection of CoxsackievirusA16. In the first column, for example, “13(112)” indicated that 112 patients in the Jinzhen group underwent the detection of CoxsackievirusA16 virus and 13 of them were identified as CoxsackievirusA16 virus-positive.
d“No.” referred to the number of patients with other enteroviruses -positive (such as CoxsackievirusA10, CoxsackievirusA6, etc.), while “(total)” referred to the total number of patients who underwent the detection of other enteroviruses. In the first column, for example, “30(55)” indicated that 55 patients in the Jinzhen group underwent the detection of other viruses and 30 of them were identified as other enteroviruses-positive.
e“No.” referred to the number of patients whose WBC counts>10,000/mm3, while “(total)” referred to the total number of patients who underwent blood routine test. Data of all participants were missing for one child from each of the two groups, while data of patients with fever was missing for one child in the placebo group.