Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2

Otu2-driven deubiquitylation of ribosomal protein eS7 impacts translational efficiency. Here, authors provide the molecular basis for recognition of monoubiquitinated eS7 on 40S and give mechanistic insights into Otu2’s role in translation reset. In this context quantitative mass spectrometry analyses of OTU2 and UBP3 pulldowns were performed.