Data from: Renal impairment on clinical outcomes following endovascular recanalization

Objective: To determine the influence of renal impairment (RI) on clinical
outcomes at 3 months and the risk of recurrent stroke in patients
presenting with emergent large vessel occlusion (ELVO) treated with
emergent endovascular treatment (EVT). Methods: Consecutive patients with
anterior-circulation stroke due to ELVO treated with EVT in 21
endovascular centers were included. Multivariate regressions were used to
evaluate the association of RI with mortality, functional independence
[modified Rankin Scale (mRS) score of 0-2], and functional improvement
(shift in mRS score) at 3 months. The association between RI and the risk
of recurrent stroke was evaluated using multivariate competing-risk
regression analyses. Results: Finally, 628 ELVO patients [(mean age, 64.7
± 12.5 years, median NIHSS score, 17 points, 99 (15.8%) with RI] who
underwent EVT were enrolled. After adjusting for other relevant variables,
multivariate regression analysis indicated that RI was independently
associated with functional independence [adjusted odds ratio (OR) 0.53,
95% confidence interval (CI), 0.29-0.96; P=0.035)] at 3 months, but not
with mortality or functional improvement. Multivariate competing-risk
regression analysis showed that patients with RI who received EVT had a
significantly higher risk of recurrent stroke [adjusted hazard ratios
(HRs) 2.56, 95% CI 1.27-5.18; P=0.009] compared to those with normal renal
function. Conclusion: Our results suggest that RI is an independent
predictor of functional independence at 3 months as well as long-term risk
of recurrent stroke in ELVO patients treated with EVT.