Krishnadimer A, an Axially Chiral Non-biaryl Natural Product: Discovery and Biomimetic Synthesis
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://figshare.com/articles/dataset/Krishnadimer_A_an_Axially_Chiral_Non-biaryl_Natural_Product_Discovery_and_Biomimetic_Synthesis/4483037
下载链接
链接失效反馈官方服务：
资源简介：
Krishnadimer
A (1a), a C2-symmetric limonoid
dimer representing a new class of axially chiral
nonbiaryl natural products, was isolated and biomimetically semisynthesized
by atroposelective 2,3-dichloro-5,6-dicyanobenzoquinone-mediated dienol-oxidative
coupling. Single-crystal X-ray diffraction and electronic circular
dichroism spectral analysis on the synthesized 1a unambiguously
established its absolute configuration, including the P-configuration of the C15–C15′ central axis. Antitumor
investigations of the synthesized dimers 1a, 2a, and 2b revealed the large impact of axial chirality
on bioactivities.
创建时间：
2016-12-19
